The nexus between the concepts of European Strategic Autonomy (EU-SA) and the European Defence Technological and Industrial Base (EDTIB) concerns the old willingness of the European Union (EU) to thrive as a global defence actor with autonomous decision-making and freedom of action. However, to do so, it is indispensable to achieve stronger technological sovereignty through balanced cooperation between Member States (MSs). The latter lack, inter alia, a common strategic culture, that is delaying the competitiveness and readiness of the European defence industry while leaving behind crucial investments in modern defence technologies. The EU finds itself in a reality where national interests prevail in a fragmented market with abundant duplicates of capabilities and collective budgetary deficiencies. For instance, this paper shall delve into the reasons why the EU is not yet a strategic autonomous and defence technological actor after actively working on this since 2013. This shall be done through an analysis of the two concepts – EU-SA and EDTIB – and an evaluation of the status quo. The final goal of this project is to prove that the prevalence of national interests over collective technological sovereignty is clogging the implementation of a tangible military-industrial base, without which the EU cannot become a strategic autonomous player in the defence industry.